October 1, 2026 · PDUFA decision
IONS PDUFA decision: a negative outcome, -5.2%
On October 1, 2026, Ionis Pharmaceuticals, Inc. reached its PDUFA decision. The result was a negative outcome, and the stock moved -5.2% in the window around the event. It had already run +9.6% in the 30 days into the catalyst — the kind of pre-event run-up that often precedes binary readouts.
The move
$61.33
1d before
$58.13
Event day
$58.09
1d after
$56.71
5d after
Our prediction vs. the result
CatalystAlert called this one neutral (+3.4% expected); the stock actually moved -5.2%. Model confidence at the time: 81%.
See the full scored track recordPre-catalyst setup
+9.6%
30-day run-up
3336%
30-day volatility
0.8×
volume spike