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The Lancet
High ImpactOriginal article

[Articles] Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial

Phase 3positiveRetatrutidePositive
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Summary

Retatrutide demonstrated substantial improvements in bodyweight and glycaemic control in Phase 3 TRIUMPH-2 trial in adults with obesity and type 2 diabetes, with a safety profile consistent with other GLP-1 receptor agonists.

Clinical Trial Data

Phase

Phase 3

Primary Endpoint

Met

Outcome Details

Retatrutide resulted in substantial improvements in bodyweight and improvements in glycaemic control with generally consistent safety profile

Importance:8/10
Sentiment:
0.85
Phase 3 DataObesityType 2 DiabetesGLP-1 AgonistWeight LossTRIUMPH-2
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Published by The Lancet on September 29, 2026 10:01 PM

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