Cell (In Press)Original article
A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration
TGF-β inhibitorPositive
AI Analysis
Summary
Research demonstrates that APOE4 induces pericyte-to-myofibroblast transition driving cerebrovascular fibrosis and amyloid accumulation. TGF-β inhibition is identified as a potential therapeutic approach to reverse this pathological remodeling in at-risk individuals.
Importance:3/10
Sentiment:
0.60
APOE4Cerebrovascular diseaseFibrosisPericyteMyofibroblastTGF-β pathwayPreclinical researchMechanism of action
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Published by Cell (In Press) on September 24, 2026 12:00 AM