Genome-Scale CRISPRi Atlas Maps Gene Function Across Human iPSCs

Summary

Researchers have developed a genome-scale CRISPRi atlas mapping transcriptional consequences for over 11,000 gene perturbations across 2.5 million human iPSCs, identifying regulators of metabolism, pluripotency, and RNA editing. The open-access resource provides a framework for investigating gene activity in pluripotent states.