Cell (In Press)Original article
The structural basis for LRRK2’s activation and autoinhibition
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Summary
Study reveals structural basis for LRRK2 activation and autoinhibition, showing how the ROC GTPase acts as a molecular switch regulating kinase activity linked to Parkinson's disease and how certain PD mutations disrupt this regulatory mechanism.
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LRRK2Parkinson's diseasekinase inhibitionstructural biologyresearch
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Published by Cell (In Press) on August 10, 2026 12:00 AM