[Articles] Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial

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Summary

A multicentre randomised controlled trial published in The Lancet demonstrates that empirical valganciclovir treatment is associated with reduced mortality in infants with severe HIV-associated pneumonia in Africa compared to standard of care, with minimal safety concerns.

Clinical Trial Data

Primary Endpoint

Met

Outcome Details

Empirical valganciclovir treatment associated with lower hazard of death in infants with severe HIV-associated pneumonia compared to standard of care alone or standard of care plus empirical tuberculosis treatment, with little evidence of associated harms

Importance:5/10

Sentiment:

0.70

clinical trialpediatricHIVpneumoniaAfricarandomized controlled trialmortality benefit

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Published by The Lancet on July 17, 2026 10:30 PM

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