[Comment] Endothelin antagonism in IgA nephropathy: promise ahead of proof?

endothelin receptor A antagonistsPositive

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Summary

The Lancet publishes a commentary on endothelin receptor A antagonists as a therapeutic target for IgA nephropathy, discussing the mechanistic rationale based on intrarenal endothelin-1 upregulation and its role in kidney disease progression.

Importance:2/10

Sentiment:

0.30

IgA nephropathyendothelin antagonismETA antagonistschronic kidney diseasetherapeutic mechanismopinion piece

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Published by The Lancet on June 4, 2026 10:15 AM

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