Cell (In Press)Original article
Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation
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Summary
Research article describing a mechanism by which toll-like receptor signaling activates proinflammatory interferon-stimulated genes through transcriptional switching from IRF2 to IRF1, mediated by proteasomal degradation via the SPOP E3 ubiquitin ligase.
Importance:2/10
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basic researchimmunologyinnate immunitytoll-like receptortranscriptional regulationinterferon signaling
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Published by Cell (In Press) on September 22, 2026 12:00 AM