GEN - Genetic Engineering & Biotech NewsOriginal article
Autism Target Discovered in Endothelial Cells in Genetic Deletion Mouse Model
P2Y2 receptor agonistPositive
AI Analysis
Summary
Researchers identified P2Y2 receptor activation in brain endothelial cells as a potential therapeutic target for autism spectrum disorder, demonstrating reversal of behavioral symptoms in a 16p11.2 deletion mouse model by increasing cerebral blood flow.
Clinical Trial Data
Phase
Preclinical
Primary Endpoint
Met
Importance:3/10
Sentiment:
0.60
autism spectrum disorder16p11.2 deletionendothelial cellsP2Y2 receptormouse modelpreclinicalneurovascularblood-brain barrier
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Published by GEN - Genetic Engineering & Biotech News on September 30, 2026 7:58 PM