<![CDATA[SRS Improves Survival Vs Hippocampal Avoidant-WBRT in SCLC Brain Metastases]]>

Phase 3positivememantinePositive

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Summary

Phase 3 NRG-CC009 trial demonstrated that stereotactic radiosurgery (SRS) improved overall survival compared to hippocampal avoidant whole-brain radiotherapy plus memantine in small cell lung cancer brain metastases, with comparable neurocognitive outcomes.

Clinical Trial Data

Phase

Phase 3

Primary Endpoint

Met

Outcome Details

SRS led to longer overall survival vs HA-WBRT plus memantine with similar neurocognitive failure in SCLC brain metastases

Importance:7/10

Sentiment:

0.70

oncologySCLCbrain metastasesSRSradiation therapyphase 3 trialNRG-CC009

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Published by Cancer Network on September 29, 2026 8:00 PM

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