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Spyre Therapeutics, Inc.

SYRE
$7.78BMid Cap

Next catalyst

Phase 2October 2026

SPY002-072

Rheumatoid Arthritis

Get an email about SYRE's next catalysts

Track Spyre Therapeutics (SYRE) and we email you when an FDA date moves, 7 days and 1 day before the decision when the exact day is known, and when it is announced. Free account, no card.

Plus 3 more upcoming events in our data (earnings, Phase 2 readout).See the timeline

Catalyst Timeline

4 upcoming, 1 past

Phase 2Next

SPY002-072 Phase 2 Est. Readout (SKYWAY-RD)

October 2026~SPY002-072285

Primary completion for SPY002-072 trial (NCT07148414) in Rheumatoid Arthritis

Source
Earnings

SYRE Earnings Report

November 2026~

Date estimated from past reporting pattern, not yet confirmed by the company | EPS Est: $-0.79 | FQ end Sep/2026 | Call: tbd

Phase 2

SPY001 Phase 2 Est. Readout (SKYLINE-UC)

June 2027~SPY001645

Estimated primary completion for SPY001 trial (NCT07012395) in Ulcerative Colitis. Topline data typically follows completion by weeks to months.

Source
Phase 2

SPY072 Phase 2 Est. Readout

October 2027~SPY072150

Estimated primary completion for SPY072 trial (NCT07766005) in Hidradenitis Suppurativa (HS). Topline data typically follows completion by weeks to months.

Source

Market Overview

Stock performance and key metrics

NASDAQPharmaceutical Preparations🇺🇸North AmericaWALTHAM95 employees
Drug Pipeline

Frequently asked questions

What is in Spyre Therapeutics, Inc.'s drug pipeline?→

CatalystAlert tracks 6 drug candidates in Spyre Therapeutics, Inc.'s (SYRE) pipeline across Phase 2. Its lead program is SPY001 (Phase 2). Each drug's phase, indication and upcoming catalysts are listed on this page.

When is Spyre Therapeutics, Inc.'s next FDA catalyst?→

Spyre Therapeutics, Inc.'s (SYRE) next tracked catalyst is a Phase 2 readout expected October 2026. See the catalyst timeline on this page for the full schedule of PDUFA dates, trial readouts and FDA events.

How do I track SYRE biotech catalysts?→

Add SYRE to your CatalystAlert watchlist for alerts ahead of each catalyst, and follow Spyre Therapeutics, Inc.'s live catalyst calendar, drug pipeline and clinical-trial timeline on this page — sourced from ClinicalTrials.gov, FDA and SEC filings.

Data is aggregated from public sources (FDA, SEC, ClinicalTrials.gov). While we strive for accuracy, information may be incomplete, delayed, or contain errors. Terms apply