CatalystAlert

Search CatalystAlert

Search for companies, drugs, and catalysts

Search CatalystAlert

Search for companies, drugs, and catalysts

Roche Holding AG

RHHBY
$351.28BMega Cap

Next catalyst

PDUFANov 30, 2026in 33 days

Giredestrant

Adjuvant ER-positive, HER2-negative stage I-III breast cancer

Get an email about RHHBY's next catalysts

Track Roche Holding (RHHBY) and we email you when an FDA date moves, 7 days and 1 day before the decision when the exact day is known, and when it is announced. Free account, no card.

Plus 64 more upcoming events in our data (Phase 3 readout, Phase 2 readout, regulatory event and more).See the timeline

Catalyst Timeline

67 upcoming, 5 past

Phase 3

Risdiplam Phase 3 Est. Readout (MANATEE)

October 2026~Risdiplam97

Estimated primary completion for Risdiplam trial (NCT05115110) in Spinal Muscular Atrophy (SMA). Topline data typically follows completion by weeks to months.

Source
Phase 3

Afimkibart Phase 3 Est. Readout (Ametrine-2)

October 2026~Afimkibart350

Estimated primary completion for Afimkibart trial (NCT06588855) in Moderately to Severely Active Ulcerative Colitis. Topline data typically follows completion by weeks to months.

Source
Phase 2

Atezolizumab Phase 2 Est. Readout (PANDA)

October 2026~Atezolizumab20

Estimated primary completion for Atezolizumab trial (NCT03448835) in Stomach Cancer. Topline data typically follows completion by weeks to months.

Source
Regulatory

Regulatory

Oct 31, 2026

RHHBY, VTRS, and IRD face key FDA drug rulings in October 2026, while MRK withdraws its application.

Source
Phase 3

Inavolisib Phase 3 Est. Readout (INAVO121)

November 2026~Inavolisib420

Primary completion for Inavolisib trial (NCT05646862) in Breast Cancer

Source
PDUFA

FDA PDUFA Date Obinutuzumab (Gazyva)

November 2026~Obinutuzumab/Intravenous

For Primary membranous nephropathy. sBLA, Priority Review; company says by November 2026, no exact day. Verified against the company announcement on 2026-10-16.

Source
Phase 2

RO7269162 Phase 2 Est. Readout

November 2026~RO7269162256

Primary completion for RO7269162 trial (NCT06402838) in Alzheimer's Disease

Source
PDUFANext

FDA PDUFA Date giredestrant (adjuvant)

Nov 30, 2026Giredestrant

For Adjuvant ER-positive, HER2-negative stage I-III breast cancer. NDA, Priority Review. Verified against the company announcement on 2026-10-16.

Source

Upcoming FDA decisions

How RHHBY's past catalysts played out

Market Overview

Stock performance and key metrics

NYSEBiotechnology🇨🇭Europe103.2K employees
Website
Drug Pipeline

Pertuzumab IV

Phase 3

Early Breast Cancer

Afimkibart

Phase 3

Crohns Disease

tocilizumab [RoActemra/Actemra]

Phase 3

Rheumatoid Arthritis

Vitamin Supplements

Phase 3

Hematological Malignancies

AT1 blocker candesartan

Phase 3

Breast Cancer

Methoxy polyethylene glycol-epoetin beta (C.E.R.A.)

Phase 3

Anemia

Mircera

Phase 3

Anemia

Saquinavir

Phase 3

HIV Infections

rituximab [MabThera/Rituxan]

Phase 3

Rheumatoid Arthritis

liposomal doxorubicin

Phase 3

Ovarian Cancer

Omalizumab

Phase 3

Nasal Polyps

csDMARDs

Phase 3

Rheumatoid Arthritis

tocilizumab

Phase 3

Rheumatoid Arthritis

ritonavir

Phase 3

HIV Infections

Etrolizumab

Phase 3

Crohn Disease

Epoetin beta

Phase 3

Anemia

rituximab (Mabthera®)

Phase 3

Warm Autoimmune Hemolytic Anemia

Lurbinectedin

Phase 3

Small-Cell Lung Cancer

taspoglutide

Phase 3

Diabetes Mellitus Type 2

Atezolizumab (MPDL3280A), an engineered anti-PDL1 antibody

Phase 3

Triple-Negative Breast Cancer

Ibandronate

Phase 3

Post-Menopausal Osteoporosis

Entrectinib

Phase 3

Solid Tumors

Methoxy Polyethylene Glycol-Epoetin Beta

Phase 3

Anemia

mycophenolate mofetil (CellCept)

Phase 3

Myasthenia Gravis, Generalized

Onartuzumab

Phase 3

Glioblastoma

Pirfenidone

Phase 3

Lung Diseases, Interstitial

Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody

Phase 3

Carcinoma, Non-Squamous Non-Small Cell Lung

Fixed Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Use (PH FDC SC)

Phase 3

Early Breast Cancer

Trastuzumab IV

Phase 3

HER2-positive Early Breast Cancer

Other Combination Anti-Cancer Therapies

Phase 3

Solid Tumors

Valganciclovir

Phase 3

Cytomegalovirus Infections

Filgrastim

Phase 3

Triple-negative Breast Cancer

Herceptin

Phase 3

Breast Cancer

Trastuzumab Emtansine

Phase 3

Breast Cancer

Fenebrutinib

Phase 3

Relapsing Multiple Sclerosis

Glofitamab

Phase 3

Diffuse Large B-cell Lymphoma

Alectinib

Phase 3

Non-Small Cell Lung Cancer

Peginterferon alfa-2a

Phase 3

Carcinoma, Hepatocellular

Cladribine

Phase 3

Lymphocytic Leukemia, Chronic

ibandronate [Bonviva/Boniva]

Phase 3

Post-Menopausal Osteopenia

Trontinemab

Phase 3

Alzheimers Disease

aleglitazar

Phase 3

Diabetes Mellitus Type 2

Alectnib

Phase 3

Carcinoma, Non-Small-Cell Lung

Chemotherapy

Phase 3

Non-Small Cell Lung Cancer

Inavolisib

Phase 3

Breast Cancer

Leucovorin (LV)

Phase 3

Colorectal Cancer

CHOP

Phase 3

Lymphoma, Large B-Cell, Diffuse

RO4917838

Phase 3

Schizophrenia

Baseline Treatment

Phase 3

Neuromyelitis Optica (NMO)

Acetaminophen/Paracetamol

Phase 3

Systemic Lupus Erythematosus

Phesgo

Phase 3

Locally Advanced or Metastatic Breast Cancer

Fludarabine Phosphate

Phase 3

Chronic Lymphocytic Leukemia

Ribociclib

Phase 3

Breast Cancer

methoxy polyethylene glycol-epoetin beta [C.E.R.A.]

Phase 3

Anemia

Ortho-Novum® 1/35

Phase 3

Rheumatoid Arthritis

PEGASYS

Phase 3

Hepatitis C, Chronic

RO7771950

Phase 3

HER2-positive Breast Cancer

aleglitazar+metformin

Phase 3

Diabetes Mellitus Type 2

dalcetrapib

Phase 3

Coronary Heart Disease

Tiragolumab and Atezolizumab

Phase 3

Cancer

Cobimetinib

Phase 3

Melanoma

DMARDs

Phase 3

Rheumatoid Arthritis

MabThera/Rituxan

Phase 3

Rheumatoid Arthritis

RO7234292

Phase 3

Huntingtons Disease

Crovalimab

Phase 3

Atypical Hemolytic Uremic Syndrome

Entecavir

Phase 3

Pediatric Immuno-Tolerant Chronic Hepatitis B

Mosunetuzumab

Phase 3

Non-Hodgkin Lymphoma

Prasinezumab

Phase 3

Parkinsons Disease

methoxy polyethylene glycol-epoetin beta (Mircera)

Phase 3

Anemia

Dalcetrapib (RO4607381)

Phase 3

Coronary Heart Disease

FEC Chemotherapy

Phase 3

Breast Cancer

Darbepoetin alfa

Phase 3

Anemia

Interferon beta-1a

Phase 3

Relapsing Multiple Sclerosis

Ibandronate, Capecitabine

Phase 3

Breast Cancer

Bevacizumab + Pemetrexed + Carboplatin

Phase 3

Non-squamous Non-small Cell Lung Cancer

Bevacizumab + Pemetrexed

Phase 3

Non-squamous Non-small Cell Lung Cancer

RO0503821 (1x/4 Weeks)

Phase 3

Anemia

Evidence-based medical care for Acute Coronary Syndrome

Phase 3

Coronary Heart Disease

Tiragolumab

Phase 3

Small Cell Lung Cancer

methoxy polyethylene glycol-epoetin beta [RO0503821, Mircera]

Phase 3

Anemia

methylprednisolone

Phase 3

Rheumatoid Arthritis

Vamikibart

Phase 3

Diabetic Macular Edema

Factor VIII (FVIII)

Phase 3

Hemophilia A

Pralsetinib

Phase 3

RET-fusion Non Small Cell Lung Cancer

Anti-VEGF Therapy

Phase 3

Neovascular Age-related Macular Degeneration

epoetin alfa or beta

Phase 3

Anemia

5-Fluorouracil, Folic acid, Capecitabine; Bevacizumab

Phase 3

Colorectal Neoplasms

Zidovudine

Phase 3

HIV Infections

Remdesivir

Phase 3

COVID-19 Pneumonia

Polatuzumab Vedotin

Phase 3

Non-Hodgkin's Lymphoma

r-HuEPO

Phase 3

Anemia

Fingolimod

Phase 3

Relapsing-Remitting Multiple Sclerosis

Teriflunomide

Phase 3

Relapsing Multiple Sclerosis

Sefaxersen (RO7434656)

Phase 3

Primary IgA Nephropathy

Standard DMARDs (Disease Modifying Anti Rheumatic Drugs)

Phase 3

Rheumatoid Arthritis

Tocilizumab (TCZ)

Phase 3

Rheumatoid Arthritis

Valganciclovir CMV Prophylaxis

Phase 3

Cytomegalovirus Infections

Herceptin IV

Phase 3

Breast Cancer

Neo-adjuvant chemotherapy

Phase 3

Breast Cancer

Enfuvirtide

Phase 3

HIV Infections

Pertuzumab

Phase 3

Breast Cancer

Taxane-based chemotherapy

Phase 3

Breast Cancer

Cyclosporine

Phase 3

Renal Transplantation

23-PPV

Phase 3

Multiple Sclerosis, Relapsing-Remitting

FAP IL2V

Phase 3

Cancer

Alimta or Taxotere

Phase 3

Non-Small Cell Lung Cancer

Oxaliplatin

Phase 3

Colorectal Cancer

Non-steroidal anti-inflammatory drugs (NSAIDs)

Phase 3

Juvenile Idiopathic Arthritis

chlorambucil

Phase 3

Lymphocytic Leukemia, Chronic

5-Fluoruracil

Phase 3

Gastric Cancer

Giredestrant

Phase 3

Endometrial Cancer

Oseltamivir IV

Phase 3

Influenza

Interferon alfa 2a

Phase 3

Renal Cell Cancer

Disease-modifying anti-rheumatic drugs

Phase 3

Rheumatoid Arthritis

Becavizumab

Phase 3

Hepatocellular Carcinoma

Azathioprine

Phase 3

Rheumatoid Arthritis

Crizotinib

Phase 3

Neoplasms

Bitopertin

Phase 3

Beta-Thalassemia

Pegylated Interferon Alfa-2a

Phase 3

Chronic Myelogenous Leukemia

Divarasib

Phase 3

Non-Small Cell Lung Cancer

Rituximab SC

Phase 3

Non-Hodgkin's Lymphoma

Optimized background antiretroviral regimen (OB)

Phase 3

HIV Infections

Permitted DMARDs

Phase 3

Rheumatoid Arthritis

Telmisartan, Bisoprolol

Phase 3

Diabetes Mellitus

exenatide

Phase 3

Diabetes Mellitus Type 2

Ocrelizumab IV

Phase 3

Relapsing Multiple Sclerosis

bitopertin [RO4917838] level 1

Phase 3

Schizophrenia

MTX

Phase 3

Rheumatoid Arthritis

erlotinib (Tarceva)

Phase 3

Metastatic Colorectal Cancer

ECC

Phase 3

Stomach Cancer

capecitabine-irinotecan

Phase 3

Advanced Colorectal Cancer

Antipsychotics

Phase 3

Schizophrenia

Prednisone/Prednisolone

Phase 3

Metastatic Prostate Cancer

Recombinant Hepatitis B Virus Vaccine

Phase 3

Hepatitis B

rFVIIa

Phase 3

Hemophilia A

Taxotere

Phase 3

Breast Cancer

Fluoropyrimidine-based Chemotherapy

Phase 3

Colorectal Cancer

CDK4/6i

Phase 3

Breast Cancer

PDS Implant Pre-Filled with Ranibizumab

Phase 3

Diabetic Retinopathy

CMF

Phase 3

Breast Cancer

Stavudine

Phase 3

HIV Infections

Ganciclovir

Phase 3

Cytomegalovirus Retinitis

tocilizumab SC

Phase 3

Rheumatoid Arthritis

Lamivudine

Phase 3

HIV Infections

Erlotinib

Phase 3

Non-Squamous Non-Small Cell Lung Cancer

satralizumab

Phase 3

Neuromyelitis Optica Spectrum Disorder

MMF

Phase 3

Lupus Nephritis

interferon-a-2a

Phase 3

Lymphoma

Baloxavir Marboxil

Phase 3

Influenza

TRO19622

Phase 3

Amyotrophic Lateral Sclerosis

XELOX

Phase 3

Colorectal Cancer

Standard adjuvant chemotherapy

Phase 3

Breast Cancer

DMARD

Phase 3

Rheumatoid Arthritis

Lebrikizumab

Phase 3

Asthma

Faricimab

Phase 3

Wet Macular Degeneration

Mycophenolate Mofetil

Phase 3

Pemphigus Vulgaris (PV)

Pegylated-interferon Alfa-2a

Phase 3

Hepatitis C, Chronic

Standard chemotherapy

Phase 3

Breast Cancer

von Willebrand Factor (VWF) Concentrates

Phase 3

Von Willebrand Disease, Type 3

Oral Corticosteroids

Phase 3

Rheumatoid Arthritis

bevacizumab, erlotinib

Phase 3

Colorectal Cancer

Corticosteroids

Phase 3

Breast Cancer

Antihistamine

Phase 3

Multiple Sclerosis

epoetin

Phase 3

Anemia

Human Coagulation Factor VIII

Phase 3

Hemophilia A

Rituximab IV

Phase 3

Lymphoma, Large B-Cell, Diffuse

Risdiplam

Phase 3

Muscular Atrophy, Spinal

Ocrelizumab

Phase 3

Multiple Sclerosis

Pegylated Interferon (PEG-IFN) alfa-2a

Phase 3

Hepatitis D, Chronic

oseltamivir

Phase 3

Influenza, Human

Gemcitabine (Chemotherapy)

Phase 3

Ovarian Cancer

Second-Line Chemotherapy

Phase 3

Non-Squamous Non-Small Cell Lung Cancer

Nelfinavir mesylate

Phase 3

HIV Infections

Zalcitabine

Phase 3

HIV Infections

Efavirenz

Phase 3

HIV Infections

Cevostamab

Phase 3

Multiple Myeloma

Etrozulimab

Phase 3

Ulcerative Colitis

Vinflunine

Phase 3

Bladder Cancer

Neoral

Phase 3

Kidney Transplantation

Gantenerumab

Phase 3

Alzheimer's Disease

anti-IL-2R

Phase 3

Kidney Transplantation

Delavirdine mesylate

Phase 3

HIV Infections

adefovir dipivoxil

Phase 3

Hepatitis B, Chronic

fusidic acid

Phase 3

Non-Small Cell Lung Cancer

PDS Implant with Ranibizumab

Phase 3

Neovascular Age-Related Macular Degeneration

PDS Implant filled with Ranibizumab

Phase 3

Neovascular Age-Related Macular Degeneration

Chemotherapy (Induction Period)

Phase 3

Non-Hodgkin's Lymphoma

tenofovir

Phase 3

Hepatitis D, Chronic

RO0503821 (1x/2 Weeks)

Phase 3

Anemia

Atezolizumab

Phase 3

Triple-Negative Breast Cancer

Fluorouracil

Phase 3

HIV Infections

Olesoxime

Phase 3

Muscular Atrophy, Spinal

Riluzole

Phase 3

Amyotrophic Lateral Sclerosis

Astegolimab

Phase 3

Chronic Obstructive Pulmonary Disease (COPD)

bitopertin [RO4917838]

Phase 3

Schizophrenia

Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 (anti-PD-L1) antibody

Phase 3

Squamous Non-Small Cell Lung Cancer

Mycophenolate mofetil (MMF)

Phase 3

Lupus Nephritis

5-Fluorouracil

Phase 3

Gastric Cancer

cyclosporine A (CsA)

Phase 3

Heart Transplantation

Platinum chemotherapy (cisplatin or carboplatin)

Phase 3

Non-Squamous Non-Small Cell Lung Cancer

Venetoclax

Phase 3

Chronic Lymphocytic Leukemia

RO7234292 (RG6042)

Phase 3

Huntington Disease

Epirubicin

Phase 3

Breast Cancer

Regorafenib

Phase 3

Colorectal Cancer

Acitretin

Phase 3

HIV Infections

Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisone/Prednisolone (CHOP)

Phase 3

Diffuse Large B-Cell Lymphoma, Non-Hodgkin's Lymphoma

Optional Endocrine Therapy of Investigator's Choice

Phase 3

Metastatic Breast Cancer

Epoetin alfa

Phase 3

Anemia

5-Fluorouracil (5-FU)

Phase 3

Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma

Leucovorin calcium

Phase 3

Colorectal Cancer

Methotrexate

Phase 3

Rheumatoid Arthritis

Gemcitabine

Phase 3

Metastatic HER2-Positive Breast Cancer

Rituximab

Phase 3

Large B-Cell Lymphoma

Trastuzumab

Phase 3

Breast Cancer

Ribavirin

Phase 3

Hepatitis C, Chronic

erlotinib hydrochloride

Phase 3

Lung Cancer

Fulvestrant

Phase 3

Breast Cancer

Bevacizumab

Phase 3

Melanoma

R-pola-mini-CHP

Phase 3

DLBCL

PTC+Pertuzumab

Phase 3

Breast Cancer

Obinutuzumab

Phase 3

Large B-cell Lymphoma

Bendamustine

Phase 3

Follicular Lymphoma

Capecitabine

Phase 3

Biliary Tract Cancer

pegylated interferon alpha2a

Phase 3

Chronic Hepatitis C

tenecteplase

Phase 3

Myocardial Infarction

background treatment

Phase 3

Tubular Breast Cancer Stage II

PEGIntron plus ribavirin

Phase 3

Chronic Hepatitis C Virus Infection

Letrozole

Phase 3

Ovarian Neoplasm Epithelial

Trastuzumab in combination with pertuzumab

Phase 3

Haematological Malignancy

Pegylated Interferon/ribavirin

Phase 3

Chronic Hepatitis C

Peginterferon alpha-2a (Pegasys®)

Phase 3

HIV Infections

Folate

Phase 3

Rheumatoid Arthritis

Zilebesiran

Phase 3

High Risk Cardiovascular Disease

XELOXA-A

Phase 3

Colorectal Cancer

KLH

Phase 3

Multiple Sclerosis, Relapsing-Remitting

epoetin beta (NeoRecormon ®)

Phase 3

Kidney Failure

Invirase

Phase 3

Directly Observed Therapy

OCR

Phase 3

Multiple Sclerosis, Relapsing-Remitting

TT Vaccine

Phase 3

Multiple Sclerosis, Relapsing-Remitting

13-PCV Booster

Phase 3

Multiple Sclerosis, Relapsing-Remitting

sirolimus versus mycophenolate mofetil

Phase 3

Diabetes Mellitus, Type 1

Obinutuzumab administration

Phase 3

Membranous Nephropathy - PLA2R Induced

Peginterferon alfa-2a + Ribavirin

Phase 3

Chronic Hepatitis c

XELOXA

Phase 3

Colorectal Cancer

LHRH Agonist

Phase 3

Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer

emtricitabine/tenofovir

Phase 3

HIV Infections

Irinotecan (CPT-11)

Phase 3

Colorectal Cancer

Ribavirin "loading" dose given

Phase 3

Hepatitis C

TRUVADA (EMTRICITABINE + TENOFOVIR DF)

Phase 3

Hepatitis B

Solanezumab

Phase 3

Alzheimers Disease

modified FOLFOX6 + bevacizumab

Phase 3

Metastatic Colorectal Cancer

Bupropion

Phase 3

Breast Cancer

HIV antiretroviral therapy

Phase 3

HIV Infections

Pertuzumab and Trastuzumab FDC SC

Phase 3

HER2-positive Early Breast Cancer

Omeprazole

Phase 3

Breast Cancer

Folinic Acid, interferon-alpha

Phase 3

Rectal Cancer

anthracycline-based

Phase 3

Breast Cancer

RO7239361

Phase 3

Duchenne Muscular Dystrophy

MabThera

Phase 3

Humoral Rejection in Kidney Transplantation

RO7204239

Phase 3

Obesity

Vemurafenib in combination with cobimetinib

Phase 3

Haematological Malignancy

trastuzumab (Herceptin®)

Phase 3

Breast Cancer

Dabrafenib in combination with trametinib

Phase 3

Haematological Malignancy

Lenvatinib

Phase 3

Unresectable Hepatocellular Carcinoma

FOLFOXIRI + Bevacizumab

Phase 3

Metastatic Colorectal Cancer

Eculizumab

Phase 3

Paroxysmal Nocturnal Hemoglobinuria

5 FU

Phase 3

Neoplasms

Abemaciclib

Phase 3

Ovarian Cancer

Intravitreal Ranibizumab

Phase 3

Diabetic Macular Edema

Administration of Methylprednisolone + Prednisone + Mycophenolate mofetil

Phase 3

Lupus Nephritis

21Capecitabine + bevacizumab + oxaliplatin

Phase 3

Colorectal Cancer

Non-Biologic DMARDs

Phase 3

Rheumatoid Arthritis

rHuPH20

Phase 3

Non-Small Cell Lung Cancer

Tociluzumab

Phase 3

Relapsed or Refractory Follicular Lymphoma

Onartuzumab (MetMAb)

Phase 3

Gastric Cancer

Infliximab

Phase 3

Ulcerative Colitis

DL-alpha-tocopherol

Phase 3

Atherosclerosis

Paclitaxel, Bevacizumab, liposomal doxorubicin, Capecitabine

Phase 3

Human Epidermal Growth Factor 2 Negative Carcinoma of Breast

Vemurafenib

Phase 3

Melanoma

Ipatasertib

Phase 3

Triple-Negative Breast Cancer

Ranibizumab

Phase 3

Diabetic Macular Edema

Emicizumab

Phase 3

Hemophilia A

erlotinib HCl

Phase 2

Non-Small Cell Lung Cancer

Azathioprine or Mycophenolate mofetil

Phase 2

Bullous Pemphigoid

Trastuzumab, Docetaxel

Phase 2

Breast Cancer

FOLFIRI + bevacizumab

Phase 2

Colorectal Cancer Metastatic

RO7269162

Phase 2

Alzheimer's Disease

Englumafusp alfa

Phase 2

Lymphoma, Non-Hodgkin

ZN-A-1041

Phase 2

Advanced Solid Tumors

RO6958688

Phase 2

Carcinoma, Non-Small-Cell Lung

Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 (PD-L1) antibody

Phase 2

Breast Neoplasms

Leuporelin acetate

Phase 2

Breast Neoplasms

RO4929097

Phase 2

Non-Squamous Non-Small Cell Lung Cancer

PTC-Pz

Phase 2

Breast Cancer

Levofolinic acid

Phase 2

Colorectal Cancer

Dual Integrin Antagonist

Phase 2

Asthma

Dendritic cell vaccination

Phase 2

Malignant Pleural Mesothelioma

Atezolizumab Cohort 7

Phase 2

Solid Tumors

boceprevir

Phase 2

Hepatitis C, Chronic

PRM-151

Phase 2

Idiopathic Pulmonary Fibrosis

Mesna

Phase 2

Lymphoma

PolyPEPI1018

Phase 2

Colorectal Cancer Metastatic

Ro 24-7429

Phase 2

Sarcoma, Kaposi

Peluntamig (PT217)

Phase 2

Small Cell Lung Cancer (SCLC)

Metronidazole Actavis

Phase 2

Non-Squamous Non-Small Cell Lung Cancer

RO7490677

Phase 2

Primary Myelofibrosis

Oxaliplatin, Irinotecan, Bevacizumab, Docetaxel

Phase 2

Gastric Cancer

Saquinavir, lopinavir, ritonavir

Phase 2

HIV Infections

mDCF

Phase 2

Anal Cancer

Topical Corticosteroid Creams (Triamcinolone acetonide and Hydrocortisone)

Phase 2

Atopic Dermatitis

Doxorubicine

Phase 2

Untreated T-cell Angioimmunoblastic Lymphoma

Second line chemotherapy

Phase 2

Breast Cancer

Gemcitabine days 1, 8, 15 of a 28 day cycle

Phase 2

Pancreatic Cancer

RO5083945

Phase 2

Non-Squamous Non-Small Cell Lung Cancer

antibody induction

Phase 2

Kidney Transplantation

Standard antipsychotic therapy

Phase 2

Schizophrenia

RO5217790

Phase 2

Cervical Intraepithelial Neoplasia

RO6864018

Phase 2

Hepatitis B, Chronic

RO5093151

Phase 2

Hypertension, Glaucoma, Open-Angle

Fulvestrant or an Aromatase Inhibitor (Physician Choice)

Phase 2

Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer

RO7268489

Phase 2

Progressive Multiple Sclerosis

Saquinavir and Ritonavir

Phase 2

HIV Infections

Calciumfolinat

Phase 2

Gastric Cancer

R+CVP+IFN

Phase 2

Non-Hodgkin's Lymphoma

ERIVEDGE

Phase 2

Basal Cell Carcinoma

RO7046015

Phase 2

Parkinson's Disease

TRO40303

Phase 2

Acute Myocardial Infarctus

Trastuzumab Subcutaneous (SC)

Phase 2

Cancer of Unknown Primary Site

Peg-interferon alpha-2a, Ribavirin

Phase 2

Chronic Hepatitis C

RO4588161

Phase 2

Hepatitis C, Chronic

Aromatase Inhibitor

Phase 2

Breast Cancer

Diphenhydramine hydrochloride (HCl)

Phase 2

Lupus Nephritis

IMM-101

Phase 2

Colorectal Cancer

Peg-interféron alpha 2a + ribavirin

Phase 2

Hepatitis

Tocilizumab (Actemra®)

Phase 2

Acute Hypoxemic Respiratory Failure

Cytotoxic Combination

Phase 2

Behcet's Syndrome

Clindamycin in hydrocortisone lotion

Phase 2

Rash

Hormonal Therapy

Phase 2

Breast Cancer

Allogeneic islets of Langerhans transplant

Phase 2

Type 1 Diabetes

CAL-101

Phase 2

Chronic Lymphocytic Leucemia

Mericitabine

Phase 2

Hepatitis C

fotemustine

Phase 2

Glioblastoma Multiforme

Induction Chemotherapy

Phase 2

Breast Cancer

gemcitabine, oxaliplatin, capecitabine

Phase 2

Locally Advanced Pancreatic Cancer

Tobemstomig

Phase 2

Urothelial Cancer

Ribavirin (drug)

Phase 2

Hepatitis C, Chronic

Interferon gamma (drug)

Phase 2

Hepatitis C, Chronic

Obinutuzumab and Pixantrone

Phase 2

Lymphoma, Non-Hodgkin

Actos

Phase 2

Diabetes Mellitus Type 2

capecitabine (Xeloda)

Phase 2

Rectal Cancer

PHY906

Phase 2

Pancreatic Cancer

Erythropoietin Beta

Phase 2

Myelodysplastic Syndromes

DOX: Docetaxel, oxaliplatin, Capecitabine

Phase 2

Gastric Cancer

Docetaxel, Leucovorin, Fluorouracil, Cisplatin

Phase 2

Gastroesophageal Junction Adenocarcinoma

Trastuzumab, Docetaxel, Bevacizumab

Phase 2

Breast Cancer

Rituximab + CHOP chemotherapy

Phase 2

Primary Gastric Diffuse-Large B-Cell Lymphoma

LABA

Phase 2

Asthma

Forimtamig

Phase 2

Relapsed or Refractory Multiple Myeloma

PEGPH20

Phase 2

Pancreatic Adenocarcinoma

Induction- PF-06480605

Phase 2

Moderate to Severe Ulcerative Colitis

RO4602522

Phase 2

Alzheimer's Disease

RO5027838

Phase 2

Diabetes Mellitus Type 2

Zifibancimig

Phase 2

Macular Degeneration

GDC-4198

Phase 2

Breast Cancer

Doxycline

Phase 2

Non-Small Cell Lung Cancer

RG1662

Phase 2

Down Syndrome

obinutuzumab (RO5072759)

Phase 2

Non-Hodgkin's Lymphoma

Iberdomide

Phase 2

Multiple Myeloma

Enicepatide

Phase 2

Overweight or Obese

capecitabine (Xeloda®)

Phase 2

Breast Cancer

Standard platinum-based chemotherapy

Phase 2

Non-Small Cell Lung Cancer

bevacizumab (Avastin)

Phase 2

Liver Cancer

Emicizumab Injection

Phase 2

Hemophilia A, Acquired

Oxaliplatine

Phase 2

Metastatic Colorectal Cancer

Mosunetuzumab (SC)

Phase 2

Follicular Lymphoma

Vemurafenib plus Cobimetinib (combination)

Phase 2

Cancer

OSI-774

Phase 2

Pancreatic Cancer

RO4876904

Phase 2

Diabetes Mellitus Type 2

Crenezumab

Phase 2

Alzheimer Disease

Obinutuzumab/Intravenous

Phase 2

Follicular Lymphoma

Samuraciclib

Phase 2

Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

Trastuzumab deruxtecan

Phase 2

HER2-positive Breast Cancer

ANA598

Phase 2

HCV Infection

Copegus

Phase 2

Hepatitis C, Chronic

N-acetylcysteine

Phase 2

Idiopathic Pulmonary Fibrosis

OpRegen

Phase 2

Age-Related Macular Degeneration

Olaparib+Bevacizumab to SCLC patients

Phase 2

Lung Cancer

Epidoxorubicin

Phase 2

Breast Cancer

RO7795081

Phase 2

Obesity or Overweight

Pravastatin

Phase 2

Dyslipidemia

Orlistat

Phase 2

Diabetes Mellitus

Tumor samples analysis

Phase 2

Triple Negative Breast Cancer

Experimental

Phase 2

Diabetic Neuropathy

Docetaxel, Cisplatin, 5-FU and Cetuximab

Phase 2

Nasopharyngeal Carcinoma

Investigator's choice of anti-cancer treatment (except immunotherapy)

Phase 2

Breast Cancer

Atezolizumab plus Tiraglolumab

Phase 2

Squamous Cell Carcinoma of the Anal Canal

Association atezolizumab + BDB001 + RT

Phase 2

Solid Tumor, Adult

Taxane (docetaxel or paclitaxel)

Phase 2

Breast Cancer

RO5190591

Phase 2

Hepatitis C, Chronic

Temozolomide (TMZ)

Phase 2

High Grade Glioma

5-FU, leucovorin, docetaxel, oxaliplatin (FLOT), trastuzumab

Phase 2

Adenocarcinoma of the Gastroesophageal Junction

RAR Gamma

Phase 2

Emphysema

Basmisanil

Phase 2

Schizophrenia

RG7774

Phase 2

Diabetic Retinopathy

Immunochemotherapy

Phase 2

Central Nervous System Lymphoma

Chronic- PF-06480605

Phase 2

Moderate to Severe Ulcerative Colitis

Rituximab and DexaBEAM

Phase 2

Relapsed Non-Hodgkin-Lymphoma

Chemotherapy (FOLFIRI regimen, FOLFOX regimen or LV5FU2 regimen)

Phase 2

Colorectal Cancer

BVZ+XELOX or BVZ+XELIRI or BVZ+FUIRI or BVZ+FUOX

Phase 2

Colorectal Cancer

Erlotinib + docetaxel

Phase 2

Non Small Cell Lung Cancer

Perjeta Injectable Product

Phase 2

Breast Neoplasms

Fosamprenavir

Phase 2

HIV Infections

Herceptin+XELOX

Phase 2

Metastatic or Recurrent Gastric Adenocarcinoma

Ocrelizumab Test Formulation

Phase 2

Multiple Sclerosis

Xeloda

Phase 2

Breast Cancer

Tocilizumab + Glucocorticoids (GCs)

Phase 2

Giant Cell Arteritis

C.E.R.A

Phase 2

Anemia

NXT007

Phase 2

Hemophilia A

Mosunetuzumab (IV)

Phase 2

B-cell Non-Hodgkin Lymphoma

beta-lactam

Phase 2

Soft Tissue Infections

Atezolizumab in

Phase 2

Extensive-stage Small Cell Lung Cancer

Rituxumab

Phase 2

B-cell Non-Hodgkin Lymphoma

SOC Agent

Phase 2

Glioblastoma

Blood sample collection

Phase 2

Squamous Cell Carcinoma of the Head and Neck

Didanosine

Phase 2

HIV Infections

Folinic Acid

Phase 2

Rectal Cancer

Polatuzumab vedotin (Liquid)

Phase 2

Lymphoma

Autogene Cevumeran

Phase 2

Muscle-invasive Urothelial Carcinoma

Carboplatin/Cisplatin

Phase 2

Nasopharyngeal Cancer

Epothilone D

Phase 2

Breast Cancer

Pertuzumab and Trastuzumab Fixed-Dose Combination for Subcutaneous Administration (PH FDC SC)

Phase 2

HER2-Positive Early Breast Cancer

Interferon alfa-2a

Phase 2

Renal Cell Cancer

Interleukin 2

Phase 2

HIV Infections

Folic Acid

Phase 2

Rheumatoid Arthritis

Endocrine therapy

Phase 2

HER2-positive Breast Cancer

GK Activator (2)

Phase 2

Diabetes Mellitus Type 2

Atezolizumab & Bevacizumab

Phase 2

Mesothelioma, Malignant

Docetaxel, Capecitabine, Cisplatin, Bevacizumab

Phase 2

Advanced Gastric Cancer

Axitinib

Phase 2

Renal Cell Carcinoma

Diprosone

Phase 2

Metastatic Colorectal Cancer

Capecitabine+Irinotecan+Bevacizumab

Phase 2

Metastatic Colorectal Cancer

Atezolizumab (MPDL3280A)

Phase 2

Lymphoma, Follicular

lenalidomide, bendamustine, rituximab

Phase 2

Mantle Cell Lymphoma

R-EPOCH and cART

Phase 2

Lymphoma, AIDS Related

TCS Cream

Phase 2

Atopic Dermatitis

Pegylated interferon alfa-2a plus nucleos(t)ide(s)

Phase 2

Chronic Hepatitis B

DPP-IV Inhibitor

Phase 2

Diabetes Mellitus Type 2

vismodegib

Phase 2

Basal Cell Carcinoma

SPK-8011QQ

Phase 2

Hemophilia A

PEGASYS [peginterferon alfa-2a]

Phase 2

Hepatitis B, Chronic

MSTT1041A

Phase 2

Asthma

Glofitamab + Obinutuzumab

Phase 2

Richter Syndrome

RO7017773

Phase 2

Autism Spectrum Disorder (ASD)

RO 205-2349

Phase 2

Diabetes

Danoprevir

Phase 2

Hepatitis C, Chronic

Tenofovir-Emtricitabine

Phase 2

Leukoencephalopathy, Progressive Multifocal

RO5024048

Phase 2

Hepatitis C, Chronic

Olesoxime (TRO19622)

Phase 2

Chemotherapy-Induced Peripheral Neuropathy

RO7247669

Phase 2

Melanoma

Tiragolumab and Atezolizumab IV FDC

Phase 2

PD-L1-selected Solid Tumors

RG7314

Phase 2

Autism Spectrum Disorder

Tociliuzumab

Phase 2

COVID-19 Pneumonia

Gemcitabine+erlotinib

Phase 2

Metastatic Pancreatic Cancer

Pertuzumab + trastuzumab

Phase 2

Elderly Metastatic Breast Cancer Population

Dinutuximab Beta

Phase 2

Neuroblastoma

TCH

Phase 2

Breast Cancer

RO7126209

Phase 2

Alzheimers Disease

Tominersen

Phase 2

Huntington Disease

FOLFIRI + cetuximab

Phase 2

Colorectal Cancer Metastatic

Obinutuzumab Injection

Phase 2

Stage II Grade 1 Follicular Lymphoma

PEG-IFN alfa-2a, Tenofovir

Phase 2

Hepatitis D

FEC

Phase 2

Breast Cancer

RO6889450

Phase 2

Schizophrenia, Schizoaffective Disorder

RO4998452

Phase 2

Diabetes Mellitus Type 2

Atezolizumab and Radiotherapy

Phase 2

Penile Cancer

fluorouracil (5FU)

Phase 2

Colorectal Cancer

Bendamustine, Rituximab, Lenalidomide

Phase 2

Chronic Lymphocytic Leukemia

MPDL3280A

Phase 2

Non-small Cell Lung Cancer

Peg-interferon alpha 2a (drug)

Phase 2

Hepatitis C, Chronic

AT-527

Phase 2

COVID-19

Atezolizumab Injection

Phase 2

Bladder Cancer

RO5190591 (Danoprevir)

Phase 2

Hepatitis C, Chronic

SGN-LIV1A

Phase 2

Metastatic Breast Cancer

FOLFOX induction regimen

Phase 2

Colorectal Cancer

Carbo/cyclo

Phase 2

Breast Cancer

rituximab (anti-CD20)

Phase 2

Sjogren's Syndrome

First line chemotherapy

Phase 2

Mantle Cell Lymphoma

bevacizumab and trabectedin

Phase 2

Ovarian Epithelial Cancer Recurrent

GA101

Phase 2

Chronic Lymphocytic Leucemia

RO4905417

Phase 2

Coronary Heart Disease, Graft Occlusion, Vascular

SSRI

Phase 2

Obsessive-Compulsive Disorder

P38 Inhibitor (4)

Phase 2

Rheumatoid Arthritis

Ceftriaxone

Phase 2

Pneumonia, Bacterial

danoprevir + ritonavir

Phase 2

Hepatitis C, Chronic

Ribavirine

Phase 2

Chronic Hepatitis C

Mycophenolate Mofetil/Mycophenolic Acid

Phase 2

Lupus Nephritis

RO5313534

Phase 2

Alzheimer's Disease

L-Leucovorin

Phase 2

Metastatic Colorectal Cancer

Balovaptan

Phase 2

Stress Disorders, Post-Traumatic

Carboplatin-based chemotherapy

Phase 2

Non-Small Cell Lung Cancer

Pegylated Interferon (Peginterferon) Alfa-2a

Phase 2

Hepatitis B, Chronic

Bendamustine and subcutaneous rituximab

Phase 2

Aggressive Lymphoma

Lomvastomig

Phase 2

Advanced or Metastatic Esophageal Squamous Cell Carcinoma

YL201

Phase 2

Thoracic Neoplasms, Lung Diseases, Small Cell Lung Carcinoma

Standard taxane therapy

Phase 2

Breast Cancer

RG3421

Phase 2

Psoriasis

2-CdA

Phase 2

Lymphoma of Mucosa-Associated Lymphoid Tissue

GC33

Phase 2

Carcinoma, Hepatocellular

Nucleos(t)ide (NUC)

Phase 2

Hepatitis B, Chronic

Mosunetuzumab is a bispecific monoclonal antibody targeting CD20 on B cells and CD3 on T cells, redirecting T cells to eliminate malignant B cells

Phase 2

Follicular Lymphoma

Ibrutinib/Bortezomib/Rituximab

Phase 2

Waldenstrom Macroglobulinemia

pralsetinib (BLU-667)

Phase 2

RET-altered Non Small Cell Lung Cancer

Trastuzumab+Docetaxel+NPLD

Phase 2

Breast Cancer

setrobuvir

Phase 2

Hepatitis C, Chronic

Polyenylphosphatidylcholine (PPC)

Phase 2

Hepatitis C

Topical clindamycin, triamcinolone acetonide soln

Phase 2

Rash

eloxatin

Phase 2

Colorectal Cancer

Trastuzumab+Docetaxel+NPLD+Bevacizumab

Phase 2

Breast Cancer

Myocet

Phase 2

Breast Cancer

docetaxel, capecitabine

Phase 2

Metastatic Breast Cancer

Bevacizumab + Capecitabine + Radiotherapy

Phase 2

Rectal Cancer

preoperative induction chemotherapy in combination with bevacizumab followed by combined radiochemotherapy with capecitabine

Phase 2

Rectal Cancer

RO4917523

Phase 2

Fragile X Syndrome

Trastuzumab and Pertuzumab (FDC SC) and T-DM1

Phase 2

Early Breast Cancer

Erlotinib, escalating dose

Phase 2

Pancreatic Cancer

Inhaled corticposteroids (ICS)

Phase 2

Asthma

Pertuzumab, trastuzumab

Phase 2

Esophageal Carcinoma

RO4995819

Phase 2

Major Depressive Disorder

Optimized Background ARVs

Phase 2

HIV Infections

Abacavir sulfate

Phase 2

HIV Infections

Tarceva (OSI-774)

Phase 2

Colorectal Cancer

RO5459072

Phase 2

Sjogren's Syndrome

Alogabat

Phase 2

Angelman Syndrome

89Zr-Df-IAB22M2C

Phase 2

Non-Hodgkins Lymphoma

Atezolizumab and Bevacizumab

Phase 2

Cancer

RO5185426

Phase 2

Malignant Melanoma

Mosunetuzumab Intravenous (IV)

Phase 2

Diffuse Large B-cell Lymphoma

ADG126

Phase 2

Advanced Liver Cancers

Breast Cancer

3 drugs in this indication

Alzheimer's disease

3 drugs in this indication

Huntington's disease

2 drugs in this indication

oncology

2 drugs in this indication

neovascular age-related macular degeneration (nAMD)

2 drugs in this indication

Obesity

2 drugs in this indication

thyroid eye disease

2 drugs in this indication

Haematological Malignancy

2 drugs in this indication

Tuberculosis infection (latent TB) identification

1 drug in this indication

dMMR/MSI-H metastatic colorectal cancer

1 drug in this indication

Unresectable Hepatocellular Carcinoma

1 drug in this indication

Paroxysmal Nocturnal Hemoglobinuria

1 drug in this indication

advanced hepatocellular carcinoma

1 drug in this indication

Non-Small Cell Lung Cancer

1 drug in this indication

Humoral Rejection in Kidney Transplantation

1 drug in this indication

muscle-invasive bladder cancer

1 drug in this indication

cyclospora detection

1 drug in this indication

Hepatitis D detection

1 drug in this indication

relapsed small-cell lung cancer

1 drug in this indication

Inflammation & Immunology diseases

1 drug in this indication

adjuvant treatment of stage III colon cancer

1 drug in this indication

Adjuvant treatment of resected stage III dMMR or MSI-H colon cancer

1 drug in this indication

relapsing multiple sclerosis in children and adolescents

1 drug in this indication

slow-growing type of blood cancer (lymphoma)

1 drug in this indication

Follicular lymphoma

1 drug in this indication

adjuvant treatment of stage III deficient DNA mismatch repair (dMMR) colon cancer

1 drug in this indication

relapsing forms of multiple sclerosis in pediatric patients aged 10 years and older

1 drug in this indication

Malaria detection

1 drug in this indication

Adjuvant treatment of Stage III colon cancer in combination with fluoropyrimidine and oxaliplatin

1 drug in this indication

lupus

1 drug in this indication

weight loss

1 drug in this indication

Duchenne Muscular Dystrophy

1 drug in this indication

ADC-resistant cancers

1 drug in this indication

Bacterial vaginosis and Candida vaginitis diagnosis

1 drug in this indication

polypoidal choroidal vasculopathy (PCV), a sub-type of neovascular age-related macular degeneration (nAMD)

1 drug in this indication

myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)

1 drug in this indication

lung cancer

1 drug in this indication

HER2-positive breast cancer

1 drug in this indication

Zika virus RNA screening in donor samples

1 drug in this indication

Asthma

1 drug in this indication

Malignant Pleural Mesothelioma

1 drug in this indication

influenza

1 drug in this indication

Myasthenia Gravis Generalised

1 drug in this indication

relapsed or refractory follicular lymphoma

1 drug in this indication

Stage III colon cancer

1 drug in this indication

Bullous Pemphigoid

1 drug in this indication

dMMR colon cancer

1 drug in this indication

thyroid eye disease (TED)

1 drug in this indication

Breast Neoplasms

1 drug in this indication

Metastatic Colorectal Cancer

1 drug in this indication

off-the-shelf CAR T (indication not specified)

1 drug in this indication

IgA nephropathy (IgAN)

1 drug in this indication

Source: CatalystAlert database (ClinicalTrials.gov, SEC EDGAR)

Frequently asked questions

What is in Roche Holding AG's drug pipeline?→

CatalystAlert tracks 538 drug candidates in Roche Holding AG's (RHHBY) pipeline across Phase 3, Phase 2. Its lead program is Obinutuzumab/Intravenous (Phase 2). Each drug's phase, indication and upcoming catalysts are listed on this page.

When is Roche Holding AG's next FDA catalyst?→

Roche Holding AG's (RHHBY) next tracked catalyst is a PDUFA date expected Nov 30, 2026. See the catalyst timeline on this page for the full schedule of PDUFA dates, trial readouts and FDA events.

How do I track RHHBY biotech catalysts?→

Add RHHBY to your CatalystAlert watchlist for alerts ahead of each catalyst, and follow Roche Holding AG's live catalyst calendar, drug pipeline and clinical-trial timeline on this page — sourced from ClinicalTrials.gov, FDA and SEC filings.

Data is aggregated from public sources (FDA, SEC, ClinicalTrials.gov). While we strive for accuracy, information may be incomplete, delayed, or contain errors. Terms apply